Pharmacological difference in zoledronic acid amorphous and crystalline form
Answers
Zoledronate (zoledronic acid, marketed by Novartis under the trade names Zometa and Reclast) is a bisphosphonate. Zometa is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer. It can also be used to treat hypercalcemia of malignancy and can be helpful for treating pain from bone metastases.
An annual dose of Zoledronate may also prevent recurring fractures in patients with a previous hip fracture.
Zoledronate is a single 5 mg infusion for the treatment of Paget's disease of bone. In 2007, the FDA also approved Reclast for the treatment of postmenopausal osteoporosis.
Structure
Thumb
Synonyms
(1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid
(1-hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid
ácido zoledrónico
Anhydrous Zoledronic Acid
Zol
Zoledronate
Zoledronic acid
Zoledronic Acid Anhydrous
Zoledronic Acid, Anhydrous