Question

Pring is a two arm, multicentre, phase iii rct of prophylactic aed (levetiracetam) versus no aed (comparator) in patients with suspected cerebral glioma

Answer 1

There is no consensus regarding the need for prophylactic anti-epileptic drug (AED) in newly-diagnosed suspected glioma patients who have not experienced seizures. Data regarding prophylactic AED use is scant and inconclusive. Most of the available evidence comes from older, small studies that enrolled patients with brain metastases and benign tumours in addition to gliomas. A definitive randomised clinical trial is needed to determine whether the policy of prophylactic AED therapy reduces the risk of first seizures in this patient population.

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Answer 2

There is no consensus regarding the need for prophylactic anti-epileptic drug (AED) in newly-diagnosed suspected glioma patients who have not experienced seizures. Data regarding prophylactic AED use is scant and inconclusive. Most of the available evidence comes from older, small studies that enrolled patients with brain metastases and benign tumours in addition to gliomas. A definitive randomised clinical trial is needed to determine whether the policy of prophylactic AED therapy reduces the risk of first seizures in this patient population.

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