Proteins are synthesised on ribosomes in the cell cytoplasm, and must be targeted to the appropriate compartment of the cell by special targeting sequences. What is likely to be the fate of a protein that contains no such targeting sequence?
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While many proteins need to be sorted to the endoplasmic reticulum, the Golgi apparatus, or the extracellular space, some proteins exist in the cytoplasm as part of their normal function.
Such proteins include actin (a structural protein) and ribosomal proteins (which assist protein synthesis).
A lack of a targeting sequence leads to cytosolic localisation and should be viewed as a default response.
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