Question

Prothrombin required for blood clotting is prodced in

Answer 1

Answer:

Prothrombin (Factor II) is a zymogen synthesized in the liver and dependent on vitamin K. When prothrombin is activated, it forms thrombin (Factor IIa).

Explanation:

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Answer 2

Explanation:

Prothrombin (factor II) is a vitamin K–dependent plasma protein synthesized in the liver. In the final common coagulation pathway, factor Xa within the prothrombinase complex (factor Va and phospholipid) cleaves an activation peptide (prothrombin fragment 1.2) from prothrombin to yield thrombin, which cleaves fibrinogen to produce fibrin, and activates platelets and factors V, VIII, XI, and XIII to form an insoluble hemostatic plug. Plasma prothrombin activity ranges from about 70% to 130%, and the amount of thrombin formed is directly proportional to the plasma prothrombin concentration.

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