pyruvic acid flow chart
Answers
Pyruvic acid production by glycolysis[edit]
In glycolysis, phosphoenolpyruvate (PEP) is converted to pyruvate by pyruvate kinase. This reaction is strongly exergonic and irreversible; in gluconeogenesis, it takes two enzymes, pyruvate carboxylase and PEP carboxykinase, to catalyze the reverse transformation of pyruvate to PEP.
phosphoenolpyruvate pyruvate kinase pyruvate
Phosphoenolpyruvate wpmp.svg Pyruvic-acid-2D-skeletal.svg
ADP ATP
Biochem reaction arrow reversible YYYY horiz med.svg
ADP ATP
pyruvate carboxylase and PEP carboxykinase
Compound C00074 at KEGG Pathway Database. Enzyme 2.7.1.40 at KEGG Pathway Database. Compound C00022 at KEGG Pathway Database.
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
[[File:
GlycolysisGluconeogenesis_WP534
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|{{{bSize}}}px|alt=Glycolysis and Gluconeogenesis edit]]
Glycolysis and Gluconeogenesis edit
Jump up ^ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".
Decarboxylation to acetyl CoA[edit]
Pyruvate decarboxylation by the pyruvate dehydrogenase complex produces acetyl-CoA.
pyruvate pyruvate dehydrogenase complex acetyl-CoA
Pyruvate wpmp.png Acetyl-CoA.svg
CoA + NAD+ CO2 + NADH + H+
Biochem reaction arrow forward YYNN horiz med.svg
Carboxylation to oxaloacetate[edit]
Carboxylation by pyruvate carboxylase produces oxaloacetate.
pyruvate pyruvate carboxylase oxaloacetate
Pyruvate wpmp.png Oxaloacetate wpmp.png
ATP + CO2 ADP + Pi
Biochem reaction arrow forward YYNN horiz med.svg
Transamination to alanine[edit]
Transamination by alanine transaminase produces alanine.
pyruvate alanine transaminase alanine
Pyruvate wpmp.png L-alanine-skeletal.svg
glutamate α-ketoglutarate
Biochem reaction arrow reversible YYYY horiz med.svg
glutamate α-ketoglutarate
Reduction to lactate[edit]
Reduction by lactate dehydrogenase produces lactate.
pyruvate lactate dehydrogenase lactate
Pyruvate wpmp.png Lactic-acid-skeletal.svg
NADH NAD+
Biochem reaction arrow reversible YYYY horiz med.svg
NADH NAD+
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