Question

Q.46)
Which of the following is indiffusible solid ans
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Answer 1

Answer:

Examples of indiffusible substances include Aspirin, Chalk, Phenobarbitone, Succinylsulphathiazole, Sulphadimidine (for oral use); and Calamine, Zinc oxide, Precipitated sulphur, Hydrocortisone, Triamcinolone acetonide (for external use).

Answer 2

Answer:

Oral-ASA, Sulphadimidine, Phenobarbitone, and Chalk

Explanation:

Indiffusable solids

Solid indiffusible compounds will not stay spread throughout the vehicle for long enough to achieve dosage uniformity. Increasing the viscosity of the continuous phase by adding thickening/suspending agent improves suspension stability and homogeneity of dispersed substance.

The majority of insoluble materials are difficult to wet and can form porous clumps in liquid.

Oral-ASA, Sulphadimidine, Phenobarbitone, and Chalk will not stay equally distributed in the vehicle long enough for a sufficient dose to be assessed.

Calamine, hydrocortisone, sulphur, and zinc oxide are used externally.