Question

Quantitative radiologic imaging techniques for articular cartilage composition: toward early diagnosis and development of disease - modifying therapeutics for osteoarthritis

Answer 1

Osteoarthritis (OA) is the most common degenerative joint disease affecting articular cartilage and other joint tissues, resulting in serious morbidity and large socioeconomic impact (1-3). In the US, 27 million people experienced OA in 2005 (4). The total cost attributed to arthritis and other rheumatic conditions in the US was 128 billion dollars in 2003 (5, 6). Due to an aging population and increasing obesity rates, OA will become even more prevalent in the next decades with an estimated 67 million Americans expected to be diagnosed with arthritis by 2030 (7). The final treatment option for OA is joint replacement, which is associated with complications, limited durability, and contributes to the high costs of OA.

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Answer 2

for articular cartilage composition: toward early diagnosis and development of disease- modifying therapeutics for osteoarthritis.