Relationship between molecular mass and density of molecular clouds
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Molecular hydrogen is difficult to detect by infrared and radio observations, so the molecule most often used to determine the presence of H2 is carbon monoxide (CO). The ratio between CO luminosity and H2 mass is thought to be constant, although there are reasons to doubt this assumption in observations of some other galaxies.[1]
Within molecular clouds are regions with higher density, where lots of dust and gas cores reside, called clumps. These clumps are the beginning of star formation, if gravity can overcome the high density and force the dust and gas to collapse.
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