Role of intracellular receptors and cell surface receptors in the target cells
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The ligand crosses the plasma membrane and binds to the receptor in the cytoplasm. The receptor then moves to the nucleus, where it binds DNA to regulate transcription. ... Many signaling pathways, involving both intracellular and cell surface receptors, cause changes in the transcription of genes.
Mechanism of Action: Hormones with Intracellular Receptors. Receptors for steroid and thyroid hormones are located inside target cells, in the cytoplasm or nucleus, and function as ligand-dependent transcription factors. ... Thus, the mechanism of action of steroid hormones is to modulate gene expression in target cells.
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