Role of ubiquitinatiom in protein degradation
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The ubiquitin (Ub)-proteasomepathway (UPP) of protein degradation. Ub is conjugated to proteins that are destined for degradation by an ATP-dependent process that involves three enzymes. A chain of five Ub molecules attached to the protein substrate is sufficient for the complex to be recognized by the 26S proteasome.
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