Question

Short note on growth S- phase of cell cycle​

Answer 1

S phase (Synthesis Phase) is the phase of the cell cycle in which DNA is replicated, occurring between G1 phase and G2 phase.Since accurate duplication of the genome is critical to successful cell division, the processes that occur during S-phase are tightly regulated and widely conserved.

Throughout M phase and G1 phase, cells assemble inactive pre-replication complexes (pre-RC) on replication origins distributed throughout the genome.[4] During S-phase, the cell converts pre-RCs into active replication forks to initiate DNA replication.This process depends on the kinase activity of Cdc7 and various S-phase CDKs, both of which are upregulated upon S-phase entry.

Activation of the pre-RC is a closely regulated and highly sequential process. After Cdc7 and S-phase CDKs phosphorylate their respective substrates, a second set of replicative factors associate with the pre-RC. Stable association encourages MCM helicase to unwind a small stretch of parental DNA into two strands of ssDNA, which in turn recruits replication protein A (RPA), an ssDNA binding protein.[ RPA recruitment primes the replication fork for loading of replicative DNA polymerases and PCNA sliding clamps.Loading of these factors completes the active replication fork and initiates synthesis of new DNA.

Complete replication fork assembly and activation only occurs on a small subset of replication origins. All eukaryotes possess many more replication origins than strictly needed during one cycle of DNA replication. Redundant origins may increase the flexibility of DNA replication, allowing cells to control the rate of DNA synthesis and respond to replication stress

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Answer 2

Explanation:

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अंग्रेजी मे अर्थ [+]

उदाहरण और उपयोग [+]

Example and Usage of पक्षी in sentences

Examples and usage of पक्षी in prose and poetry

पक्षी (Word) वाक्यांश का उपयोग आलेख/ गद्य में

"इस पर पापबुद्वि कांपने लगा और बोला, महाराज, वह पेड़ पक्षी है।"

- पक्षी शब्द का उपयोग शशिप्रभा गोयल ने अपनी कहानी बदी का फल इस प्रकार किया है.

"राजा पक्षी की उन बातों का मतलब नहीं समझा तो उसने मुझसे उनका मतलब पूछा।"

- पक्षी शब्द का उपयोग रामकांत दीक्षित ने अपनी कहानी पंछी बोला चार पहर इस प्रकार किया है.

"पर पक्षी की पहेलियां मेरी समझ