Biology, asked by Shreyaeshwari7958, 10 months ago

Significance of bland excipient in buccal tablets

Answers

Answered by ravirajasdfghjkl74
1

Answer:

The treatment of breakthrough pain (BTP), a transitory exacerbation of pain that occurs on a background of otherwise-controlled, persistent pain, requires an opioid formulation and/or method of administration that can provide rapid and extensive systemic exposure. Fentanyl buccal tablet (FBT; FENTORA®, Cephalon, Inc.) employs OraVescent® drug delivery technology, which enhances the rate and extent of fentanyl absorption. OraVescent technology enhances the oral dissolution and buccal absorption of fentanyl, which facilitates rapid uptake of fentanyl into the bloodstream, reducing gastrointestinal absorption and minimizing extensive first-pass metabolism. The resulting pharmacokinetic profile of FBT is characterized by greater bioavailability and a higher early systemic exposure compared with the earlier oral transmucosal fentanyl citrate formulation. In clinical studies of opioid-tolerant patients with cancer-related and noncancer-related BTP, FBT has provided consistent and clinically relevant improvements in pain intensity and pain relief relative to placebo, with a safety and tolerability profile that is generally typical of that observed with other potent opioids. The pharmacokinetic properties of FBT allow for meaningful clinical efficacy, with an onset of action that closely matches the onset of BTP. PMID:20634985

Answered by shailendrachoubay456
0

The  Buccal Tablets

Explanation:

  • The Buccal tablets is a small, flat tablet, intended to be held between the cheek and teeth.
  • The Buccal and sublingual tablet is flat, oval flat intended to be dissolved in the buccal pouch(buccal tablet) or beneath the tongue (sublingual tablet) for absorption through the oral mucosa.
  • Excipients are used in medicines to facilitate the manufacture .
  • The Bland Excipients are used to avoid salivary stimulation.
  • The Excipients used in the formulation of sublingual tablets,The most common route of drug Administration in which drug through the mouth, such as Capsule, tablet, Syrup.

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