Question

Significance of complexation effficiency in cyclodextrin complexation

Answer 1

Answer:

Complexation with cyclodextrin (CD) is known as an effective method for enhancing dissolution properties and bioavailability of poorly soluble drugs. ... In general, complexation efficiency of cyclodextrins is rather low, and thus, relatively large amounts of cyclodextrins are needed to complex small amounts of drug.

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Answer 2

Answer:

A complexation efficiency of 0.1 suggests that one out of 11 cyclodextrin molecules forms a complex with the drug. If the complexation efficiency is 0.01, then only one out of 100 cyclodextrin molecules forms a complex.

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