size reduction of powder is not possible , if particles do not contain flaws or crackers .explain
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Size reduction is a process of reducing large solid unit masses into small unit masses, coarse particles or fine particles. Size
reduction process is also termed as comminution or diminution or pulverizations. In addition to the standard adjustments of
the milling process (i.e., speed, screen size, design of rotor, load), special techniques of milling may be useful including special
atmosphere, temperature control, sonocrystallization, supercritical fluid process. etc. Moreover, some advance technologies
of size reduction including Micron Technologies, Gran-U-Lizer™ Technology, Jet-O-Mizer™ and Microfluidics® have
been popular. Various application of size reduction concept covers oral delivery of poorly soluble drugs, micronization,
nanotechnology (micro- and nano suspensions), etc. This systemic review highlights advantages and disadvantages, mechanisms,
theories, techniques, advances, and pharmaceutical applications of size reduction technology.