smooth muscles ,cardiac muscles and organs are regulated by
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In smooth muscle, the contraction is not controlled voluntarily by the somatic nervous system, but by signals from the autonomous nervous system, such as nerve impulses, hormones, and other chemicals released by specialized organs.
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Nitric oxide is formed via nitric oxide synthase in endothelial cells; it is then able to diffuse out of the endothelium into smooth muscle cells. Nitric oxide then induces the conversion of guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP) by binding to and activating the enzyme guanylyl cyclase
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