Question

Solubility enhancement of poorly soluble drugs

Answer 1

Answer:

Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include micronization, nanonization, ...

Sparingly soluble: 30 – 100

Insoluble: > 10,000

Definition: Parts of solvent required for one part of solute

Very slightly soluble: 1000 – 10,000

Answer 2

There are various techniques to enhance the drug solubility such as particle size reduction, nanosuspension, use of surfactants, salt formation, solid dispersion, etc. From this article it may be concluded that solid dispersion is an important approach for improvement of bioavailability of poor water-soluble drugs.