Solubility enhancement of poorly soluble drugs
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Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include micronization, nanonization, ...
Sparingly soluble: 30 – 100
Insoluble: > 10,000
Definition: Parts of solvent required for one part of solute
Very slightly soluble: 1000 – 10,000
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There are various techniques to enhance the drug solubility such as particle size reduction, nanosuspension, use of surfactants, salt formation, solid dispersion, etc. From this article it may be concluded that solid dispersion is an important approach for improvement of bioavailability of poor water-soluble drugs.
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