Question

Solvent used with sodium hydroxide for deprotonation of imidazole

Answer 1

hey

Explanation:

I want to deprotonate imidazole so that it may react with bromoester by knocking out Br- ion. But all the reactants are not soluble in a single (common) solvent like DMSO, CH2Cl2, CHCl3,..

.Please suggest me a suitable solvent and base combination to carry out this reaction. The ester bears a 16-C chain in its structure

Answer 2

Sodium hydride is a common reagent for substrate activation in nucleophilic substitution reactions. Sodium hydride can behave both as a base and as a source of hydride. This dual ability in the presence of an electrophile such as benzyl bromide results in the formation