Question

Some mucins are secreted and can form gels - what we call mucus! What special linkages, characterised by oxidised cysteine residues, are necessary for the formation of these gels?​

Answer 1

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Disulphide bridges✔✔✔

Disulphide bridges describe a covalent bond between two sulphur atoms found in the amino acid cysteine.

Gel-forming mucins contain a central domain rich in serine and threonine (which allow O-linked glycan formation) and peripheral regions rich in cysteine allowing disulphide bonds to form with other mucins.

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Answer 2

Answer:

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Disulphide bridges describe a covalent bond

between two sulphur atoms found in the amino acid cysteine.

Gel-forming mucins contain a central domain rich

in serine and threonine , and peripheral regions rich in

cysteine allowing disulphide bonds to form with other mucins.