State the role of APC and MPF in human reproduction
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Maturation-promoting factor (abbreviated MPF, also called mitosis-promoting factor or M-Phase-promoting factor) is the cyclin-Cdk complex that was discovered first in frog eggs. It stimulates the mitotic and meiotic phases of the cell cycle.
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Cyclin B is degraded by a Destruction-box motif (D-box) in its primary sequence, which is recognized by the E3 ligase Anaphase Promoting Complex/Cyclosome (APC/C). ... At fertilization, Ca2+ stimulates APC/C activity, in mouse about 6-fold [23], such that cyclin B degradation results in MPF loss.
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