Biology, asked by hariom176, 1 year ago

synthesis of folate‑chitosan nanoparticles loaded with ligustrazine to target folate receptor positive cancer cells

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Answered by Cheemaking
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In addition to its vasodilatory effect, ligustrazine (LZ) improves the sensitivity of multidrug resistant cancer cells to chemotherapeutic agents. To enhance the specificity of LZ delivery to tumor cells/tissues, folate‑chitosan nanoparticles (FA‑CS‑NPs) were synthesized by combination of folate ester with the amine group on chitosan to serve as a delivery vehicle for LZ (FA‑CS‑LZ‑NPs). The structure of folate‑chitosan and characteristics of FA‑CS‑LZ‑NPs, including its size, encapsulation efficiency, loading capacity and release rates were analyzed. MCF‑7 (folate receptor‑positive) and A549 (folate receptor‑negative) cells cultured with or without folate were treated with FA‑CS‑LZ‑NPs, CS‑LZ‑NPs or LZ to determine cancer‑targeting specificity of FA‑CS‑LZ‑NPs. 


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