Differentiate between rough and smooth endoplasmic reticulum.
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Rough Endoplasmic Reticulum (RER)Smooth Endoplasmic Reticulum (SER)It possesses ribosomes attached to its membrane.It does not have ribosomes on its membrane.Formed of cisternae and a few tubules.Formed of vesicles and tubules.It participates in the synthesis of enzymes and proteins.Synthesises glycogen, lipids and steroids.It helps in the formation of lysosomes.Gives rise to Spherosomes/ OleosomesIt is internal and connected with the nuclear envelope.It is peripheral and may be connected to plasmalemma.Ribophorins are present and help ribosomes attach to ERDevoid of Ribophorins.It might develop from the nuclear envelopeDevelops from Rough Endoplasmic Reticulum.
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Smooth endoplasmic reticulum (SER) is a type of endoplasmic reticulum consisting of tubular vesicles that lack ribosomes on the outer surface and is involved in the synthesis and storage of lipids.
Rough ER has ribosomes on the outer surface. Smooth ER doesn' thave ribosomes on the outer surface.