The administration of mifepristone with misoprostol disrupts pregnancy decidual necrosis
Answers
Antagonists of progesterone have the potential to be used to interrupt a wide range of reproductive processes that are dependent on this key hormone. Compounds such as mifepristone, onapristone, and lilopristone interact with progesterone receptors throughout the body and block the action of endogenous progesterone. The effect of mifepristone on the ovarian and endometrial cycles depends on the stage of the cycle. Throughout the follicular phase there is little effect on the endometrium. In the early follicular phase it has little effect on the ovarian cycle. In contrast, in midfollicular phase, gonadotropin levels are suppressed and follicular development is arrested. In the early luteal phase, the corpus luteum forms normally, but the development of secretory endometrium is retarded. In the mid- and late luteal phases, bleeding is provoked due to an effect on the endometrium, while luteal regression occurs inconsistently.