Question

The ones who are crazy enough to change the world are the ones that do meaning

Answer 1

This usually means that, if you have the power to do something different and elevate the people in this world to a whole new level, you're going to make a change to this world.

Being crazy usually means that you are different.

Being mad means that you are unique

Answer 2

Means if you are having a unique talent unlike others... are actually intelligent and can do miracles