The year is 1960. Mr. X has felt depressed for a number of years. He has tried several different medications to alleviate his feelings of hopelessness and lack of motivation, but nothing seems to help. Recently, however, his doctor has prescribed IPRONIAZID, a new medication reported to be of benefit in many cases of depression. He tells him that researchers think the drugs act by inhibiting an enzyme in the brain called monoamine oxidase(MAO).MAO is one of the enzymes responsible for catecholamine degradation. Because it is a new drug, its potential adverse effects are not well defined, so his doctor advises Mr. X to report any unusual effects of the medication.Hopeful, but not expecting significant changes, Mr. X begins taking the medication. Within a few weeks, he begins to feel motivated and energetic for the first time in 20 years. Exuberant at his newly found sense of energy, Mr. X reclaims his past life and socialite by hosting a gala wine and cheese receptionThe best and brightest of city are invited, and the party is looking to be a success. As he stands up to give thanks to his attendees, Mr. X celebrates with a large swig (Large amount swallows by gulp) of his favorite 1954 Chianti(wine) ). By the end of the party, Mr. X has a severe headache and nausea. Recalling his doctor’s warning, Mr. X has a friend rush him to the nearest hospital. In the emergency department, the attending physician records a blood pressure of 230/160mm Hg. Recognizing that Mr. X is experiencing a hypertensive emergency, The doctor quickly administers Phentolamine (an α-adrenoceptor antagonist). Mr. X’s blood presssure quickly normalizes, and the doctor’s subsequent clinical investigation identifies a new, and now-famous,drug-food interaction involving MAO inhibitors. Q1. What is he mechanistic explanation for the interaction of MAO inhibitors with red wine and aged cheese ? Q2. How does phentolamine act, and why was it useful in this clinical circumstance ? Q3. Why didn’t his physician use a β-adrenoceptor antagonist to treat Mr. X’s hypertension ? *
Answers
Answered by
0
Answer:
p
p
p
p
p
p
p
p
p
p
A
p
p
A
p
p
p
p
p
p
p
p
p
p
p
p
p
p
p
p
p
p
p
p
p
p
A
p
p
p
A
p
p
p
p
p
p
p
p
p
p
p
p
p
p
p
A
p
A
p
6
54
60
Similar questions