Question

There are three major causes for elevated levels of uric acid such as gout, renal disease, and a higher rate of nucleic acid breakdown. High levels of uric acid are also found secondary to a variety of diseases, such as glycogen storage disease and congenital enzyme deficiency.

Answer 1

Answer:

This condition of elevated uric acid level in blood is called hyperuricemia.

The primary causes are gout and the secondary causes are renal failure, glycogen storage disorders ( Von gierke's disease), higher nucleic acid catabolism.

The main effect is accumulation of urate crystal in the synovial fluids of joints causing tremendous pain especially in the 1st metatarsophalangeal joint.

Accumulation of urate crystal in cooler parts of the body causes tophi.

Treatment: Preventing intake of alcohol,

administration of colchicine, xanthine oxidase enzyme inhibitor like allopurinol,etc.

Hope you will be able to understand.

Answer 2

Answer:

$There are three major causes for elevated levels of uric acid: gout, renal disease, and a higher rate of nucleic acid breakdown. High levels of uric acid are also found secondary to a variety of diseases, such as glycogen storage dis- ease and congenital enzyme deficiency.$