Question

Today, she weighs twenty-one stones (make it negative) without changing its meaning

Answer 1

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The answer:

Today, she weighs no more than twenty-one stones.

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Answer 2

Upon changing the affirmative sentence today, she weighs twenty-one stones into a negative sentence without changing the meaning of the given sentence will be today she weighs not less than twenty-one stones.

Or you can also write it in another way which is today she weighs not more than twenty-one stones. This will make the sentence negative without changing its meaning.