Two major differences between regeneration and fragmentation.
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REGENERATION : It is the process to regenerate or renewal.
FRAGMENTATION: It is a process in which any thing broken down into many other (small or large) fragments.
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Fragmentation is when an organism is split into fragments, and each fragment grows into complete, individual organisms that are clones of the original organism. Regeneration is the process of regrowth that organisms that allows for partial or complete regrowth of tissue after a damaging event.
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