Question

Under which of the following conditions will there be no change in the reading frame of fbllowing mRNA ?
5' AACAGCGGUGCUAUU 3'
(1) Insertion of G at 5th position
(2) Deletion of G from 5th position
(3) Insertion of A and G at 4th and 5th positions respectively
(4) Deletion of GGU from 7th 8th and 9th positions

Answer 1

4th option is the correct option

Answer 2

Deletion of GGU from 7th 8th and 9th positions won't change the reading frame.

Explanation:

• The genetic information is stored in the DNA in form of genes.

• And the gene contains the genetic information in form of nitrogen bases in particular sequence.

• The nitrogen bases are read in group of three nucleotides per time so as to get the particular amino acid during translation.

• With the deletion of three nucleotides in 7th 8th and 9th positions, the amino acids that was being coded by the three nucleotides as a codon won't be coded anymore.

• But the genetic frame will get shifted by one codon from after that.

• So the full genetic makeup Won't get disturbed.

• Thus, deletion of these 3 nucleotides won't interfere with genetic frame of the group of codons.

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If there are 999 bases in an RNA that codes for protein with 333 amino acids, and the base at position 901 is deleted such that the length of RNA becomes 998 bases, how many codons will be altered?