Question

What are irreversible inhibitors?

Answer 1

An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity. Since blocking an enzyme's activity can kill a pathogen[1] or correct a metabolic imbalance, many drugs are enzyme inhibitors[2][3]. They are also used in pesticides. Not all molecules that bind to enzymes are inhibitors; enzyme activators bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Answer 2

Irreversible inhibition is different from irreversible enzyme inactivation.

Irreversible inhibitors are generally specific for one class of enzyme and do not inactivate all proteins.

They do not function by destroying protein structure but by specifically altering the active site of their target.

EXAMPLES

1. malathion,
2. parathion,
3. chlorpyrifos

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