What are spontaneous mutations?
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brief word on nomenclature
Spontaneous mutations are alleles of initially unknown genes and are given allele names and symbols based on their phenotype (e.g. diabetes, db). Recessive mutations (i.e. requiring two copies of the mutated allele to manifest the phenotype) are represented by all lower-case letters while dominant (i.e. one or two copies of the mutated allele produces the phenotype) and semidominant (i.e. one mutant allele produces an intermediate phenotype) spontaneous mutations are represented by an upper-case first letter, followed by lower-case letters. Once the gene responsible for the mutant phenotype has been identified, the allele symbol is superscripted to an approved gene symbol
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