What are the advantages and disadvantages of using viral vectors for gene therapy?
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Risks and disadvantages of the Adeno-Associated Virus include integration, decline in expression over time due to episomal loss by degradation, small packaging capacity, low titers, and a strong immune response. ... The risks of using the viral vector in gene therapydo not outweigh the potential benefits
The most important advantage that retroviral vectors offer is their ability to transform their single stranded RNA genome into a double stranded DNA molecule that stably integrates into the target cell genome. This means thatretroviral vectors can be used to permanently modify the host cell nuclear genome.
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