What are the different types of PRRs and what is their function?
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Answer:
Upon a microbial infection, the body needs to be alerted to the presence of potential harmful pathogens. This is achieved through specialised receptors known as pattern recognition receptors (PPRs) which are predominantly expressed on immune cells.
These receptors recognize conserved molecular structures known as pathogen- or damage-associated molecular patterns (PAMPs and DAMPs) that are found in microbes such as bacteria, viruses, parasites or fungi. These motifs are usually specific to the micro-organism (i.e. they are not present in the host and therefore are considered as “non-self”). They are also essential for its viability and thus less subjected to changes which would make otherwise their recognition by the host more difficult.
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