Question

what are the drawbacks of handwritten manuscripts

Answer 1

if it helps
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Answer 2

1) The hand written manuscripts were very fragile highly expensive, difficult  to handle and could not be carried around easily.

2) The handwritten manuscripts were written in different styles so understanding the script was not easy and hence could not be read and copied easily.

3) Copying of the manuscripts was very expensive, laborious, tedious and time consuming work.

Hope it helps you my dear friend...