What are the genetic effects on consanguineous and cross cousin marriages?
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In clinical genetics, a consanguineous marriage is defined as a union between two individuals who are related as second cousinsor closer, with the inbreeding coefficient (F) equal or higher than 0.0156 (Bittles 2001), where (F) represents a measure of the proportion of loci at which the offspring of a consanguineous ...
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Consanguineous marriages are associated with an increased risk for congenital malformations and autosomal recessive diseases, with some resultant increased postnatal mortality in the offspring of first cousin couples, but demographic and socioeconomic confounders need to be well controlled.
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