Question

what are the importance of Philadelphia chromosome?​

Answer 1

Explanation:

The discovery in Philadelphia in 1960 of the Ph chromosome was a landmark. It was the first consistent chromosome abnormality found in any kind of malignancy. The discovery led to the identification in CML cells of the BCR-ABL fusion gene and its corresponding protein.

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Answer 2

The importance of Philadelphia chromosome is:

● The Philadelphia chromosome or Philadelphia translocation (Ph) is a particular hereditary anomaly in chromosome 22 of leukemia malignancy cells (especially constant myeloid leukemia (CML) cells).

● The Philadelphia chromosome structures when chromosome 9 and chromosome 22 break and trade parcels.

● This makes a strangely little chromosome 22 and another mix of directions for your cells that can prompt the improvement of incessant myelogenous leukemia.