what are the major difference between particles and substance
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Particles are the smallest unit of a substance and and an element is a substance that is made entirely from one type of atom. So everything is made up of a substance, the particle is the smallest unit and the elements is a substance but not just as big as a natural substance.
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The difference between elements and particles is that a particle is typically a package of mass and is way to small to be considered a element. The difference between substance and element is a substance is a form of matter that takes up space and an element is a pure substance that can NOT be broken down.
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