Question

What are the pros and cons of the Gene Therapy Gendicine?

Answer 1

Explanation:

Gendicine is a recombinant adenovirus engineered to express the tumor-suppressing gene p53 for patients with head and neck squamous cell carcinoma. It was approved by the Chinese Food and Drug Administration in 2003 [127]. When combined with chemotherapy and radiotherapy, gendicine can improve treatment efficacy 3.4-fold (a complete regression of tumors occurred in 64% of cases when gendicine was combined with radiotherapy as against 19% with radiotherapy alone) in addition to its ability to ameliorate any associated toxicity [128]. Furthermore, gendicine has been shown to improve the therapeutic effect of radiation in pancreatic cancer cells [129]. However, clinical trials in pancreatic cancer are yet to follo