What contains all the information required to fold the polypeptide chain in its 3-d structure?
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★ The native conformation of a protein is determined by its amino acid sequences. This Hypothesis was proved by an experiment in which Denaturation is followed by renaturation folds the chain in its native structure.
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Folded proteins are held together by various molecular interactions. During translation, each protein is synthesized as a linear chain of amino acids or a random coil which does not have a stable 3D structure. ... Folding of proteins into their correct native structure is key to their function
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