what does a quinolone do
Answers
Explanation:
Quinolones inhibit replication of bacterial DNA by blocking the ligase domain of bacterial DNA gyrase (topoisomerase II); some also inhibit topoisomerase IV. These enzymes relax DNA supercoils and enable DNA replication and repair . The effect of quinolones is bactericidal.
Answer and Explanation:
A quinolone antibiotic is a member of a large group of broad-spectrum bacteriocidals that share a bicyclic core structure related to the substance 4-quinolone. They are used in human and veterinary medicine to treat bacterial infections, as well as in animal husbandry.
Nearly all quinolone antibiotics in use are fluoroquinolones, which contain a fluorine atom in their chemical structure and are effective against both Gram-negative and Gram-positive bacteria. One example is ciprofloxacin, one of the most widely used antibiotics worldwide.