what happens to telomere end after ageing
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However, telomerase has not been detected in normal somatic cells, and these cells lose telomeres with age. ... Second, if cells senesce after 80 doublings in vitro, mean telomere length decreases about 4000 base-pairs, but one or more telomeres in each cell will lose significantly more telomeric DNA.
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In these cells telomere length is maintained after DNA replication and the cells do not show signs of ageing. ... If telomerase activity was switched off in cancer cells, their telomeres would shorten until they reached a 'critical length'. This would, prevent the cancer cells from dividing uncontrollably to form tumours.
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