Question

What happens to the cell cycle if both p53 alleles are mutated?

Answer 1

Ans.

p53 is a tumor-suppressor gene that codes for a protein, TP53 (tumor protein 53) or p53. It is known as 'guardian of the genome' as it plays important role in prevention of DNA mutations and conserve genomic stability. T

The p53 protein regulates cell division and functions as tumor-suppressor protein by triggering apoptosis or programmed cell death in cells, when DNA is damaged or mutated.

When both copies or alleles of p53 gene are mutated, it leads to formation of altered p53 protein that cannot trigger the apoptosis and is unable to control cell proliferation.

Thus, 'it will result into uncontrolled cell proliferation of mutated cells that can leads to cancer.'

Answer 2

Cell cycle in mutation

Explanation:

• When each copies or alleles of p53 sequence square measure mutated, it ends up in formation of altered p53 super molecule that can't trigger the cell death and is unable to manage cell proliferation. Thus, 'it can result into uncontrolled cell proliferation of mutated cells which will ends up in cancer.
• Inactivation of the p53 neoplasm suppressor could be a frequent event in tumorigenesis. In most cases, the p53 sequence is mutated, giving rise to a stable mutant super molecule whose accumulation is considered an indicator of cancer cells.
• Mutant p53 proteins not solely lose their neoplasm restrictive activities however usually gain extra oncogene functions that endow cells with growth and survival benefits. curiously, mutations within the p53 sequence were shown to occur at completely different phases of the multistep method of malignant transformation, so tributary differentially to neoplasm initiation, promotion, aggressiveness, and metastasis.