Question

What is a determining factor as to whether or not a virtual machine can have multiple NICs connected to it?

Answer 1

Well a virtual machine can have multiple nic's connected.There are common to have different subnets for  front end  and back to back end connection.

Multiple nic's are connected to multiple subnets and also vm.

Those subnets lies in the same virtual network..

These are the determining factor as to whether or not a virtual machine can have a multiple nic's.