What is brain fever? Write it's causal organism and symptoms?
Answers
Brain fever describes a medical condition where a part of the brain becomes inflamed and causes symptoms that present as fever. The terminology is dated and is encountered most often in Victorian literature, where it typically describes a potentially life-threatening illness brought about by a severe emotional upset. Conditions that may be described as brain fever include:
Encephalitis, an acute inflammation of the brain, commonly caused by a viral infection.
Meningitis, the inflammation of the membranes covering the brain and spinal cord.
Cerebritis, inflammation of the cerebrum.
Scarlet fever, infectious disease whose symptoms can include paranoia and hallucinations.
Answer:
Introduction: A taller-than-wide (TTW) shape is a suspicious feature of thyroid nodules commonly defined as an anteroposterior/transverse diameter (AP/T) ratio >1. An intraobserver variability of up to 18% in AP diameter evaluations has been described, which may lead to overreporting of this feature. To potentially improve the reliability of the TTW definition, we propose an arbitrary ratio of ≥1.2. Objective: The aim of this study was to estimate the impact of this definition on diagnostic performance. Methods: We prospectively analyzed 553 thyroid nodules referred for cytology evaluation at an academic center. Before fine-needle aspiration, two examiners jointly defined all sonographic features considered in risk stratification systems developed by the American Thyroid Association (ATA), the American Association of Clinical Endocrinologists (AACE), the American College of Radiology (ACR TIRADS), the European Thyroid Association (EU-TIRADS), and the Korean Society of Thyroid Radiology (K-TIRADS). TTW was defined according to the current definition (AP/T diameter ratio >1) and an arbitrary alternative definition (AP/T ratio >1.2). Results: The alternative definition classified fewer nodules as TTW (28, 5.1% vs. 94, 17%). The current and proposed definitions have a sensitivity of 26.2 and 11.9% (p = 0.03) and a specificity of 83.8 and 95.5% (p < 0.001).
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