Question

What is CCR5 DELTA 32 MUTATION? What are its disadvantages?

Answer 1

"A genetic mutation known as CCR5-delta 32 is responsible for the two  types of HIV resistance that exist. CCR5-delta 32 hampers HIV's ability  to infiltrate immune cells. The mutation causes the CCR5 co-receptor on the outside of cells to develop  smaller than usual and no longer sit outside of the cell. CCR5 co-receptor is like door that allows HIV entrance into the cell. The  CCR5-delta 32 mutation in a sense locks "the door" which prevents HIV  from entering into the cell. 

Answer 2

A genetic mutation known as CCR5-delta 32 is responsible for the two types of HIV resistance that exist. CCR5-delta 32 hampers HIV's ability to infiltrate immune cells. The mutation causes the CCR5 co-receptor on the outside of cells to develop smaller than usual and no longer sit outside of the cell.

To date, several studies have indicated that CCR5 delta32 mutations provide significant resistance to smallpox,¹⁴ in addition to enhancing certain forms of memory¹⁵ but also render individuals more vulnerable to influenza¹⁶ and the West Nile virus. In mice, CCR5 deficiency exacerbates stroke-related brain injury.

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