what is chemical found in cherry to reduce uric acid
Answers
The answer is 'anthocyanin compounds'.
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Gout is an excruciatingly painful inflammatory arthritis caused by the crystallization of uric acid within joints. The prevalence of gout in the US was estimated to be 3.9% of US adults based on the National Health and Nutrition Examination Survey 2007-2008, which translates into 8.3 million US adults (1, 2). While the pathophysiology of gout is well-characterized and efficacious pharmacological regimens are available, many patients with gout continue to experience recurrent gout attacks (3, 4). Such attacks cause tremendous pain and suffering and are a major cause of morbidity.
Over the past few decades, cherries have garnered considerable public attention and interest from both patients and investigators as potentially effective options in the prevention and management of gout. Small experimental studies in healthy human subjects and animals have demonstrated that cherry consumption lowers serum uric acid levels (5, 6). Others have reported that cherry products contain high levels of anthocyanins (7-9) that possess anti-inflammatory and antioxidant properties (8, 10-12). Furthermore, some cherry producers have claimed that cherry products have the potential to reduce the pain associated with gout (13) and some patients use cherries as a strategy to avoid and/or treat gout attacks (14). However, to our knowledge, no study has assessed whether consumption of cherries lowers the risk of gout attacks, as reflected in warning letters sent to various cherry-based product manufacturers by the Food and Drug Administration about the lack of sufficient data regarding their claims of disease-related benefits of cherry products (13).
To help address this relevant knowledge gap, we analyzed 633 gout patients who were prospectively recruited from across the United States in an online gout study (15). In this study, we used a case-crossover design to quantify the relative risk of gout attack after cherry intake as compared with no cherry intake and its potential modification by allopurinol use and major gout risk factors.