What is Friedel-Crafts alkylation and Friedel-Crafts acylation reactions? Explain with examples
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Answer:
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Explanation:
A Friedel-Crafts reaction is an organic coupling reaction involving an electrophilic aromatic substitution that is used for the attachment of substituents to aromatic rings. The two primary types of Friedel-Crafts reactions are the alkylation and acylation reactions. These reactions were developed in the year 1877 by the French chemist Charles Friedel and the American chemist James Crafts.
Answer:
alkyl group can be added to a benzene molecule by an electrophile aromatic substitution reaction called the Friedel‐Crafts alkylation reaction. One example is the addition of a methyl group to a benzene ring.
The mechanism for this reaction begins with the generation of a methyl carbocation from methylbromide. The carbocation then reacts with the π electron system of the benzene to form a nonaromatic carbocation that loses a proton to reestablish the aromaticity of the system.
1. An electrophile is formed by the reaction of methylchloride with aluminum chloride.
2. The electrophile attacks the π electron system of the benzene ring to form a nonaromatic carbocation.
3. The positive charge on the carbocation that is formed is delocalized throughout the molecule.
4. The aromaticity is restored by the loss of a proton from the atom to which the methyl group has bonded.
5. Finally, the proton reacts with the AlCl 4 − to regenerate the AlCl 3 catalyst and form the product HCl.
Carbocations can rearrange during the Friedel‐Crafts alkylation reaction, leading to the formation of unpredicted products. One example is the formation of isopropyl benzene by the reaction of propyl chloride with benzene.
The isopropyl benzene results from a rearrangement of the initially formed propyl carbocation to the more stable isopropyl carbocation.
This rearrangement is called a 1,2-hydride ion shift. A hydride ion is H−.