Question

what is Gabriel pthalimide reaction

Answer 1



Potassium phthalimide is a -NH2-synthon which allows the preparation of primary amines by reaction with alkyl halides. After alkylation, the phthalimid is not nucleophile and does not react anymore. Product is cleaved by reaction with base or hydrazine, which leads to a stable cyclic product.

Mechanism of the Gabriel Synthesis

Note: Phthalimide is acidic!





Cleavage:



Answer 2

The gabriel synthesis is a chemical reaction that transforms primary alkyl halides into primary amines. Traditionally, the reaction uses potassium phthalimide. The reaction is named after the German chemist Siegmund gabriel.


it's written in my *book*