what is glycoprotein
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hi....Glycoproteins are proteins that contain oligosaccharide chains covalently attached to polypeptide side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification.
azadhashmi:
what is oligosacchride
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Glycoproteins are a class of proteins which have a glycosyl group (or glycans-carbohydrates) attacthed to their protein chain. The process that results in the formation of glycoproetins is glycosyaltion and its a post Translational modification.
glycan group attatched to the N-terminal part of the protein chain as seen in figure
3. Function : Glycoproetins are a part of integral membrane proteins.
b. They play a vital role in cell-cell interactions and pathogenic response by the hosts.
c. Regulatory mechanisms in phosphorylation based cell signalling.
d. found in platelets; provide functional stability to them
e. BEST EXAMPLES OF GLYCOPROTEINS: A,B.O BLOOD GROUPING system;
A-type have a specific antigen or glycoprotein coated on it
B-type have another specific antigen or glycoprotein coated on it
O-type have none of the above.
f. gp14 and gp120 are HIV viral coat proteins. (next hotspot for cancer research)
g. All the important hormones like LH,FSH, TSH, HCG for pregnancy, EPO have glycoproteins as playing a functionally specific role in their functional activation.
h. Myelin signalling and memory encoding addictions in the prefrontal cortex.
4. different types of glycoproteins are based on the different processes of glycosyaltion which give glycoproteins that differ in the placement of glycan part as their substitution groups.
Different processes are:
N-GlycosylationO-GlycosylationP-GlysosylationC-Glycosylation
5. the sugar part’s substitution and position solely determine the protein’s folding mechanism( which means that it is different for each glycoprotein- based purely on the sugar residue and not on the protein residue)
6. Glycosylation has been shown to be necessary for the secretion of invertase and acid phosphatase by yeast cells and several classes of immunoglobulins by some mouse plasmacytoma cell lines, although this does not appear to be the case for a variety of other proteins.
7. Where are they seen mostly ?: Cell membrane, extracellular fluids (ECF)
8. Who secretes them the most ?: Golgi apparatus.
9. In genetics : RNA Pol I trancribes VSG( Varinat surface glycoproteins) for transcription.
10. Muti-drug resistance in mammals have been given by a mdr1 gene that encodes a high molecular weight P-glycoprotein- that attacks cross linked lyophilic molecules.
glycan group attatched to the N-terminal part of the protein chain as seen in figure
3. Function : Glycoproetins are a part of integral membrane proteins.
b. They play a vital role in cell-cell interactions and pathogenic response by the hosts.
c. Regulatory mechanisms in phosphorylation based cell signalling.
d. found in platelets; provide functional stability to them
e. BEST EXAMPLES OF GLYCOPROTEINS: A,B.O BLOOD GROUPING system;
A-type have a specific antigen or glycoprotein coated on it
B-type have another specific antigen or glycoprotein coated on it
O-type have none of the above.
f. gp14 and gp120 are HIV viral coat proteins. (next hotspot for cancer research)
g. All the important hormones like LH,FSH, TSH, HCG for pregnancy, EPO have glycoproteins as playing a functionally specific role in their functional activation.
h. Myelin signalling and memory encoding addictions in the prefrontal cortex.
4. different types of glycoproteins are based on the different processes of glycosyaltion which give glycoproteins that differ in the placement of glycan part as their substitution groups.
Different processes are:
N-GlycosylationO-GlycosylationP-GlysosylationC-Glycosylation
5. the sugar part’s substitution and position solely determine the protein’s folding mechanism( which means that it is different for each glycoprotein- based purely on the sugar residue and not on the protein residue)
6. Glycosylation has been shown to be necessary for the secretion of invertase and acid phosphatase by yeast cells and several classes of immunoglobulins by some mouse plasmacytoma cell lines, although this does not appear to be the case for a variety of other proteins.
7. Where are they seen mostly ?: Cell membrane, extracellular fluids (ECF)
8. Who secretes them the most ?: Golgi apparatus.
9. In genetics : RNA Pol I trancribes VSG( Varinat surface glycoproteins) for transcription.
10. Muti-drug resistance in mammals have been given by a mdr1 gene that encodes a high molecular weight P-glycoprotein- that attacks cross linked lyophilic molecules.
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