Question

What is going to happen if the brain cells are not arrested in G0 phase?​

Answer 1

Answer:

If the brain cells are not arrested in G$0$ phase, DNA damage detection and repairing program will not occur.

Explanation:

The cell cycle is a series of process that takes place in a cell as it grows and divides into daughter cells. It is divided into two basic phases- the Interphase and M (mitosis) phase. Interphase includes three further phases- G$1$, S, G$2$ phases. Some cells in the adult animal undergo division occasionally, and some others do not exhibit division. These cells exit the G$1$ phase and enter into the G$0$ phase (quiescent stage or inactive phase). The cells in G$0$ are needed to replace cells that are lost in cell injury or cell death.

In the brain, neurons also contain this same cell cycle machinery, but they do not often use it for cell division. They stay in the G$0$ phase, once it is differentiated into adult neurons and do not divide further. If any damage occurs in the DNA, the neurons from G$0$ detect the damage and repair the program by exiting the G$0$ phase and reactivating the cell cycle, and go back to the G$0$ phase. Only the neurons from G$0$ can do this repairing damages. So, if the neurons are not arrested in the G$0$ phase, the damaged DNA will not get detected and repaired.    

Answer 2

If the brain cells are not arrested in G0 phase are :

• The G₀ category describes the cellular state outside the recurring cell cycle.
• In general, cells were thought to enter G₀ primarily due to environmental factors, such as a deficiency of nutrients, which limited the resources needed for proliferation.
• So it was thought of as a rest period.
• G₀ is now known for taking various forms and occurs for many reasons.
• Cells enter the G0 phase from the cell cycle test site in the G1 phase.
• This usually happens due to a lack of growing nutrients.
• During the G0 phase, the cell cycle machinery is dissolved and cyclins and cyclin-dependent kinases disappear.
• In some cases, a conditional difference is made between the G0 cell and the 'silent' cell (e.g., heart muscle cells and neurons), which may never enter the G1 cell, while other G0 cells may.
• Cells enter the G0 phase from the cell cycle test site in the G1 phase, as a limitation (animal cells).