Question

What is haemophilia? Why is it more common in men then women?​

Answer 1

• ᴛʜᴇsᴇ ᴅɪsᴏʀᴅᴇʀs ᴀғғᴇᴄᴛ ᴍᴀʟᴇs ᴍᴏʀᴇ ᴏғᴛᴇɴ ᴛʜᴀɴ ғᴇᴍᴀʟᴇs ʙᴇᴄᴀᴜsᴇ ғᴇᴍᴀʟᴇs ʜᴀᴠᴇ ᴀɴ ᴀᴅᴅɪᴛɪᴏɴᴀʟ x ᴄʜʀᴏᴍᴏsᴏᴍᴇ ᴛʜᴀᴛ ᴀᴄᴛs ᴀs ᴀ “ʙᴀᴄᴋ-ᴜᴘ.” ʙᴇᴄᴀᴜsᴇ ᴍᴀʟᴇs ᴏɴʟʏ ʜᴀᴠᴇ ᴏɴᴇ x ᴄʜʀᴏᴍᴏsᴏᴍᴇ, ᴀɴʏ ᴍᴜᴛᴀᴛɪᴏɴ ɪɴ ᴛʜᴇ ғᴀᴄᴛᴏʀ ᴠɪɪɪ ᴏʀ ɪx ɢᴇɴᴇ ᴡɪʟʟ ʀᴇsᴜʟᴛ ɪɴ ʜᴇᴍᴏᴘʜɪʟɪᴀ. ғᴇᴍᴀʟᴇs ᴡɪᴛʜ ᴀ ᴍᴜᴛᴀᴛɪᴏɴ ᴏɴ ᴏɴᴇ x ᴄʜʀᴏᴍᴏsᴏᴍᴇ ᴀʀᴇ ᴄᴀʟʟᴇᴅ “ᴄᴀʀʀɪᴇʀs”.

Answer 2

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These disorders affect males more often than females because females have an additional X chromosome that acts as a “back-up.” Because males only have one X chromosome, any mutation in the factor VIII or IX gene will result in hemophilia. Females with a mutation on one X chromosome are called “carriers”.

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Why is haemophilia more common in males than females?

Males are affected more often than females because the gene is located on the X chromosome. Hemophilia. Hemophilia is a disorder in which the blood cannot clot correctly because of a lack of a clotting factor called factor VIII.

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